Antonio Valencia is Manchester United's major injury concern.
The Ecuador wide-man suffered a nasty knock on his ankle at Liverpool last week and Sir Alex Ferguson rates Valencia as "doubtful".
Darren Fletcher and Scott Wootton are both in the United squad but are unlikely to play from the outset and Robin van Persie and Wayne Rooney could start together for the first time.
Brad Friedel will return in goal for Tottenham.
Hugo Lloris will be on the bench and defender Kyle Naughton could return after missing last week's win over QPR with a foot injury he sustained against Lazio.
Emmanuel Adebayor (hamstring), Scott Parker (Achilles), Jake Livermore (groin), Benoit Assou-Ekotto and Younes Kaboul (both knee) are out.
Manchester United (from): Lindegaard, De Gea, Rafael, Evans, Ferdinand, Wootton, Evra, Buttner, Nani, Fletcher, Scholes, Anderson, Cleverley, Carrick, Kagawa, Rooney, Van Persie, Welbeck, Hernandez.
Tottenham (from): Lloris, Friedel, Gomes, Cudicini, Smith, Gallas, Dawson, Walker, Vertonghen, Caulker, Naughton, Falque, Huddlestone, Mason, Bale, Lennon, Sandro, Dembele, Dempsey, Sigurdsson, Carroll, Townsend, Defoe, Obika.