Man City midfielder Samir Nasri looks set to miss the clash against his former club with a hamstring injury.
Striker Sergio Aguero is poised to make his first appearance since the opening match after overcoming a knee problem while manager Roberto Mancini has said there are no disciplinary issues concerning forward Mario Balotelli.
Defender Joleon Lescott will hope to reclaim his place but right-back Micah Richards (ankle) remains sidelined.
Arsenal will again be without first-choice goalkeeper Wojciech Szczesny because of an ankle problem so Vito Mannone retains his place.
Jack Wilshere (ankle) and Emmanuel Frimpong (knee) both returned to training this week, but are still some way from first-team contention.
Czech winger Tomas Rosicky (hamstring) and French defender Bacary Sagna (broken leg) are expected to feature within the next fortnight.
Man City (from): Hart, Pantilimon, Wright, Maicon, Zabaleta, Kompany, Lescott, K Toure, Nastasic, Kolarov, Clichy, Nasri, Milner, Sinclair, Y Toure, Barry, Garcia, Rodwell, Silva, Aguero, Dzeko, Balotelli, Tevez, Razak.