Arsenal will have goalkeeper Wojciech Szczesny available again following a rib injury for the visit of Saints.
Winger Theo Walcott will be assessed after missing England's draw with Ukraine because of a virus, while midfielder Abou Diaby is 50/50 after picking up a minor knee problem when playing for France.
Midfielders Tomas Rosicky (hamstring), Jack Wilshere (ankle) and Emmanuel Frimpong (knee) all continue their rehabilitation along with defender Bacary Sagna (broken leg).
New singings Gaston Ramirez and Maya Yoshida could be involved for the first time for Southampton.
Fellow new boy Emmanuel Mayuka will also be pushing for a starting role after his substitute appearance against Manchester United, while Guly do Prado may be dropped after this week admitting drink-driving.
Danny Fox is in contention after overcoming a groin injury that ruled him of international duty with Scotland, while Jack Cork is close to a return from an ankle problem picked up in pre-season.
Arsenal (from): Szczesny, Jenkinson, Vermaelen, Mertesacker, Gibbs, Cazorla, Diaby, Oxlade-Chamberlain, Arteta, Podolski, Giroud, Mannone, Koscielny, Ramsey, Santos, Coquelin, Walcott, Gervinho, Djourou.
Southampton (from): K Davis, Gazzaniga, Richardson, Butterfield, Clyne, Fox, Shaw, Yoshida, Hooiveld, Fonte, Seabourne, Stephens, Chambers, Ward-Prowse, Do Prado, Chaplow, Cork, De Ridder, Ramirez, Lallana, Schneiderlin, Puncheon, Hammond, S Davis, Lambert, Lee, Rodriguez, Mayuka.